Archival Overview
Brilliant Belgian biochemist who pioneered molecular embryology, demonstrating in 1933 that DNA resides exclusively in the cell nucleus while RNA is present in the cytoplasm, and proving RNA's direct role in protein synthesis.
Biographical Record
Son of celebrated embryologist Albert Brachet, Jean graduated in medicine from the Université Libre de Bruxelles (ULB) in 1934. Using ingenious cytochemical staining (methyl green-pyronin) and enzymatic ribonuclease digests, he investigated sea urchin and amphibian eggs.
Years before the double helix was discovered, Brachet showed that RNA is synthesized in the nucleus and transferred to cytoplasmic ribonucleoprotein particles (ribosomes) to direct protein synthesis. His landmark books Chemical Embryology and The Biological Role of Ribonucleic Acids founded modern molecular developmental biology.
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Final Resting Place
Perpetual MemorialIxelles (Brussels), Belgium